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How long does fluconazole stay in your system

What is Fluconazole?

Fluconazole, often referred to as Diflucan is an antifungal synthetic drug with a wide range of effectiveness and is used to treat various fungal diseases.

It is typically utilized to combat yeast-related infections and, based on the way in which the drug functions typically, it can be taken as a single pill to treat.

How long does fluconazole stay in your system

The time fluconazole requires to be cleared from your system will differ depending on the individual.

Fluconazole is excreted primarily through the kidneys, therefore maintaining a healthy kidney function is an key factor in determining the amount of time it will take for fluconazole be eliminated out of your body.

When kidney functioning is in good order The half-life of fluconazole ranges between 20 and 50 hours, with 30 hours being considered normal.

It takes about 5.5 half-lives for a substance to be cleared of the body.

If we take the half-life average for fluconazole (30 hours) it would mean the average amount of length of time that it takes for fluconazole to be removed out of the body of a healthy adult is around 165 hours, or less than seven days.

If you’ve ever wondered how it is possible to treat yeast infections with only one pill of fluconazole. This is the reason.¬†It can last for a long time within the body.

Alcohol with Fluconazole

The consumption of alcohol with fluconazole isn’t contraindicated since fluconazole does not cause specific drug interactions.

But, alcohol should be taken in moderation, or with care when taking fluconazole because it may raise the chance of stomach adverse reactions.

Taking certain other anti-infective medications, such as metronidazole (which is an anti-protozoal/antibiotic), with alcohol can cause a “disulfiram-like” reaction.

The disulfiram-like response is caused by a medicine or natural substance that triggers the hypersensitivity of alcohol which causes symptoms that may be severe and may include:

  • Nausea
  • Vomiting
  • Headache
  • Abdominal discomfort
  • Flushing

Factors to take into consideration that could affect how fluconazole is able to last longer within the body

Because every patient’s physiology and biochemistry is distinct There are a variety of variables to take into consideration when determining how long Fluconazole remain within your system. In determining the length of time Fluconazole remain within your system take into consideration the following key aspects:


  • Your metabolism is the primary factor in how quickly you digest food, beverages and other medications like Fluconazole. If you are a slow metabolizer this will mean it takes longer for your body take in and eliminate Fluconazole out of your system as compared to those with fast metabolism.


  • The younger you are more youthful, the better your body’s ability to perform. Fluconazole can be removed from your system faster when your body functions better.
  • Use frequency: Fluconazole remains inside your system for the duration the time you’ve taken it. For instance, a person that has taken Fluconazole for a long time will take longer to get rid of Fluconazole from their body than someone who has only been taking Fluconazole for a short period of time.

The function of the kidneys as well as the liver functions:

  • Like everything else is eliminated via the kidneys and liver. If your kidneys or your liver are compromised, it is likely to take longer to remove Fluconazole out of your system.


  • The higher the dosage of Fluconazole you’re taking the longer it takes to allow Fluconazole to get eliminated completely from the system.¬†Genes are the reason why people are predisposed to certain metabolic processes that affect the way your¬†body processes substances¬†such as Fluconazole.¬†This means that when you are determining the length of time Fluconazole will be within your system it is important to consider your genes¬†composition¬†is a factor.

Fluconazole’s removal is primarily via renal excretion, with approximately 80 percent of the dose being absorbed into the¬†urine¬†as a pure medication in accordance with studies.¬†About one-quarter of dose is eliminated from the urinary tract as waste.

Fluconazole has the plasma half-life of about 30 hours. Pharmacokinetics in healthy individuals and those who are elderly are similar.

Based on research that have been conducted, after 4 to 5 half-lives, from 94 to 97% of the medication is eliminated. This means that after 4 to 5 half-lives the plasma concentration of a certain drug will be lower than the threshold of clinical significance and thus considered to be eliminated.

Fluconazole will be eliminated out of your body in one week (150hrs up to 7 days) following the dose you had previously taken.



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